Mass Effect/2: Punching the reporter. 'nuff said.
Metal Gear Solid 4: Guns of the Patriots - The point when Otacon calls you and asks you to change to disk 2. There was a big smile on my face =)
Duke Nukem 3D : In “Lunar Apocalypse”, when you first walk on the moon and dozens of flying robots come out of nowhere :fffuuu:
Epic moment.
Fight versus Red from Pokemon Heartgold/Soulsilver with the epic music theme
Hyrule Castle Town, Ordon Village. You can pick up puppies, but you can’t throw them :[
Ahh I see ;3
When is that game ever gonna come out? kinda reminds me of something…:retard:
the very first and last scene in conker’s bad fur day. I wasn’t sure it it was horrible or amazing when I first saw it. A game that was so humorous all of a sudden gets dark and serious. Making a perfect extension of the opening, completely tricking the player on the emotions that they thought they were perceiving.
FireTime: I loved Conker’s all the way up until the end…and then when it got serious, I suddenly didn’t like the game any more and it ruined the entire game for me. It was like Old Yeller for me. 
Eli’s death in Half Life 2: Episode 2.
Mirrors Edge ending. Saving your sister.
Red Faction Guerilla had some pretty special moments as well, especially the part where you brother gets killed, and you smash that EDF Soldier in the face.
The ending to Assassins Creed II was a bit of a mind boggler, but awesome anyway.
Just Cause 2: Jumping out of a helicopter about to explode only to find ten Elites in front of you, realizing that you are about to die, then having the helicopter fall on the elites. Freakin’ awesome.
no
That was the most half-assed horrible intro to a game ever. The game was fun to play but the story… I only have two words do that games story line. Wasted potential.
I know the feeling. As I said I wasent sure if it was the worst or best ending ever. Bit one thigs positive because of it it totally was a downer ending that required the player to freek out and want more. Makes me so mad that when Microsoft bought out rare they canceled the development of CBFD2. Rare publicly stated that if microsoft gave them the go ahead they would be all over it.
Personal preferences, Firetime. Personal preferences… :3
However, even though it was only a trailer, the Croft Manor being blown up in the Tomb Raider Underworld Trailer was purely awesome.
Outcast - The whole story
Mafia - The church & hotel part
I| like the bit in RFG where you have to rush everybody out of the town before EDF energy guys come and blow it up.
Killing Floor-Play suicidal for first time and seeing freshpound.
Half-Life 2: Episode 1-Seeing zombine for first time.
Half-Life 2: Episode 2-Death of Eli.
Actually I have two such moment in my game life. The first is from NFS most wanted. When I get BMW M3 GTR car at the first race reward. My friend told me I am lucky because the whole game is to get this car and I got it at the first round. And the another moment is I complete whole IGI-2 in one sitting and I feel like a solder.
Blowing up Megaton at night in fallout 3 
Mass Effect 2: meeting Thane for the first time, actually
EDIT: scratch that, most epic moment in ME2 was starting up the game not actually knowing what to expect, never having played such a game before, playing for a bit and suddenly stumbling out of a door into space. The scenery was just breathtaking. 