I looked for a way to not kill the companion cube but failed to find one so I just burned it. Gotta do what ya gotta do. As far as little sisters I usually play as the good guy to begin with so I didn’t have issues with it later but when I did do it I know that its just a game.
Burining the cube.
I actually didn’t care about the little sisters. A little too cliche if you ask me. (Well, tries to be anyway)
The cube, I had no problem with.
As stated before, I too searched for an alternate way to complete Chamber 17 to no avail, so I just burned it. Never played Bioshock 2. I own it, but it’s on the 360 so it’s just sitting on the shelf. If I did play however, I would probably save them, but then play through again and harvest 'em with no remorse. Very few games/tv shows/songs/movies have made me remorse for deaths really.
A sidequest in Xenogears managed to be more emotional than both of the OP’s choices. A player punch that came completely out of left field. I actually felt guilty for killing an earlier boss because of it.
The American government stole my soul along with my left kidney.
Therefore neither were difficult…
Both are simple clicks on either the keyboard or mouse, pretty easy tasks.
I can’t say. i mean sure the lil sisters had a personality, but chell woulda been creamed without companion cube! and not ONCE did it try to stab me in the back 
it didn’t talk either but hey! i woulda felt kinda crappy bout throwin to the fire. I used the lil sisters when i needed them. Felt bad sumtimes, but oh well. i stood around waiting for a different chance to “dispose” of the cube, but it never came. Atleast u had a choice with sisters 
so if i had to choose, i wuld go with the box cuz it didnt have that chance.
Good to see this thread is back. I was truly good and productive.[/Sarcasm]
I’m pretty sure the reason why some people feel more guilty when killing the companion cube, is because they actually develop an attatchment to it. The way the game introduces the companion cube makes it sort of feel like the companion cube is alive. There is only one companion cube, it can never be replaced, Little Sisters, on the other hand, come and go. Besides, the companion cube will never threaten to stab you. The little sisters command giant men in scuba gear to drill you a new one.
Pffffft :lol:
You get attached to it if you want to. I couldn’t stop laughing when the computer voice tried to make me get attached to the cube and to make me feel bad about destroying it. Getting actually attached to a cube with a pink heart on its 6 faces? Come on, wake up, it’s a fucking joke!
That’s actually my point. It IS ridiculous. But it still happens. I actually kinda got a little attatched to Dog’s Ball in HL2 when I took it to Ravenholm. Dog’s Ball, though, is a lot more excusable to become attatched to… considering it moves and makes noise, whereas the companion cube… sits there.