A Legitimate (as in Nintendo-made) PC Pokemon game that spans all regions of the worlds as seen in-game.
So basicly a bunch of gameboy ports mashed together?
I’d play it.
[COLOR=‘Blue’]Aliens Vs.[COLOR=‘RedOrange’]Predator [COLOR=‘Orange’]2 (Next in the reboot; hopefully good this time around)
[COLOR=‘DarkOrange’]Half-Life 2: Episode: 3 (Obviously)
[COLOR=‘Orange’]Warcraft 4 (Another Warcraft RTS)
[COLOR=‘RoyalBlue’]Star Wars: Jedi Knight 3 (New Dark Forces game)
[COLOR=‘Red’]Zombie Panic: Source: 2
[COLOR=‘Yellow’]Star Wars: Battle-Front 3
[COLOR=‘YellowGreen’]FarCry 3
[COLOR=‘PaleGreen’]Day Of Defeat 2
And most importantly:
[COLOR=‘Magenta’]Capcom V.s. SNK 3
Yes, it will be awesome!!!
Several of mine have already been mentioned so I’ll skip them.
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Freelancer 2
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Homeworld 1 Remake
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Battlefield Earth (Based on the BOOK, not the abomination, and done by a talented developer who will stay true the story and universe (or universes, rather))
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Spore 2 (Less childish, more scientifically accurate, more detailed space stage)
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Half-Life 2 Remake (Modernized levels/graphics. Perhaps a mod that is what Half-Life 2: Source 2 should have been.)
It is already announced, do a back flip now.
I forgot to mention in my other post:
Jet Set Radio 3
Skies of Arcadia 2
Oh yeah another Jet Set Radio game would be fantastic.
As long as they keep all of the licensed music unlike the first game. (in the non-Japanese versions)
Though it’d still probably be awesome with half the tracks missing.
A Grim Fandango remake with the latest shiny engine or Grim Fandango 2.
Crysis 3.
Jedi Knight 4 definitely.
Mass Effect 4.
A true sequel to Out of This World by Eric Chahi, even though he didn’t want one 
A sequel to The Movies.
A new Fable game that plays more like the first one (II & III were just bad game-play wise.)
A Tomba! reboot still in the original 2D with 3D background format.
A XIII remake.
A remake of Full Throttle & Day of the Tentacle akin to the Monkey Island remakes.
An HD remake of all the Kings Quest games.
A Viewtiful Joe Reboot
A remake of Invisible War so that it doesn’t suck ass
wtf. I was just going to post that but decided not to.
Yoo hooo, mister tentacle guuyyyy!
Not a “game” per se, but if Bioware released a Mass Effect 2 SDK I would come buckets.
An HD re-release or a true sequel to Freespace 2 or TIE Fighter would make me spurt out my spine.
I’m assuming this thread allows for made-up game designs, as it doesn’t specify.
I know it would never happen, but, I would like a FPS game that is a real life simulator. That way, someone could experiment with different consequences in the game that they normally wouldn’t dare to do in real life.
On a more realistic scale, I want a realistic war RTS that takes into account ALL variables that real militaries need to.
Alright, enough of my day-dreaming. 
System Shock 3
Freespace 3
(Sadly it will NEVER happen)
I would also say X-wing and Tie-Fighter, BUT I did see this today https://firingsquad.com/news/newsarticle.asp?searchid=24154 It gives me hope!!
Also Doom (original) re-make, but as Doom 4 has been announced and we know it will be going back to a similar fashion, again gives me hope!
Syphon Filter for PC
Spyro for PC
Gunman: Chronicles 2
Half-Life 3
Opposing-Force 2
Knights of the Old Republic 3
Age of Mythology 2
Empire Earth 3
Freedom Fighters 2
WarCraft 4